Real Man - Chapter 644:

The formless ancient world was infested with despicable demons. They hunted and feasted on mankind, keeping the human civilization constantly in a weak and suppressed state.

During the first known year, a magical mountain descended into the world from the realm of the Gods. Carved on this enormous mountain was a message: ‘Heaven Prevails’…

After the Grand Descent, a name that was given to the descending of the mountain, the Three Great Sages made their ways to Mystic Mountain where they learned to harvest what we now call magic, establishing the Mystic Cults and eighty-one sacred shrines to help aid mankind with the cult’s mystic powers against the eternal fight to the death with demons.

- Description from Novelupdates

“I'm going out to do something, so I can't take care of you any more. You can go down the mountain and have fun. But if you can't find someone who matches your Innate Pure Yang Body in three years, you're finished!”These were the last words the old man, who was Lionel Yeager's teacher, threw to him before he vanished. Meanwhile, having mastered most of his master's skills, Lionel Yeager went down the mountain and took his first step into civilization for the first time in years.With his unparalleled medical and martial arts, he sets forth on a journey, befriending new allies and crushing all the enemies that stand in his way, as he attempts to resolve his Pure Innate Yang Body constitution, and cultivate to the top of the world!

In the 5th year of Konoha’s founding.The battle between Hashirama Senju and Madara Uchiha at the Valley of the End had come to a close.In order to treat his elder brother’s injuries, Tobirama Senju resurrected a medical ninja from ancient times, hoping that this individual could prevent the injuries from shortening his brother’s lifespan.This medical ninja’s name was Emiya Shigen.