Transmigration: Raising the Child of the Male Lead Boss (WN) - Chapter 501

Su Shuilian was the first legitimate daughter of a renowned embroidery family, but she was murdered by her jealous family member. After death, Su Shuilian’s soul enters an unknown female body who lives in a dynasty she had never heard of.

While trapped in the wilderness with her wolf pup companions, Shuilian picks up an assassin who was betrayed by his organization and saves him from the brink of death.

After making it out of the dangerous forest, the two travel to a small town with few inhabitants. There, they find a location with a picturesque scenery and disguise themselves as a married couple to buy a house to settle down in.

She was a girl unfamiliar to this world, and he was an infamous assassin. Journey with them as they adapt to their new life…

- Description from Novelupdates

Vahn was an atypical youth. Due to a rare mutation, his blood had the potential to target and attack ailments within the human body. Touted as a universal cure, people had elevated his status above the norm and given him the classification "Panacea". In the media, he was hailed as a great hero who would usher in a new era or human wellness. However, behind the scenes things weren't so bright. Being a unique individual, Vahn spent his entire youth locked up in a lab with various scientists and research teams using his body and blood to perform endless amounts of experiments. The only solace in his suffering was the various anime and manga made available to him between experiments. He often imagined himself as the protagonist in a world of his own, finally in control of his own destiny. For years he nurtured this desire, until at the age of 14 he died when an organization had tried to kidnap him from the lab...

Eight hundred years ago, Xie Lian was the Crown Prince of the Xian Le kingdom. He was beloved by his citizens and was considered the darling of the world. He ascended to the Heavens at a young age; however, due to unfortunate circumstances, was quickly banished back to the mortal realm. Years later, he ascends again–only to be banished again a few minutes after his ascension.

Now, eight hundred years later, Xie Lian ascends to the Heavens for the third time as the laughing stock among all three realms. On his first task as a god thrice ascended, he meets a mysterious demon who rules the ghosts and terrifies the Heavens, yet, unbeknownst to Xie Lian, this demon king has been paying attention to him for a very, very long time.

- Description from Novelupdates

The main character has been reincarnated, and he possesses a system and a powerful treasure. Using these, he plans to create his own universe. Keep reading to find out more.