Surgery Godfather-Chapter 1914 - 1320: Getting Vaccinated with My Son
Berlin, Charité Medical College, it’s nearly midnight.
The lights are still on in Professor Mainshtan’s laboratory. He has been stationed there for over a month, with his White Gown wrinkled and his glasses pushed up on his forehead, but the light in his eyes is becoming increasingly bright. 𝑓𝓇𝘦ℯ𝘸𝘦𝑏𝓃𝑜𝘷ℯ𝑙.𝑐𝑜𝓂
Data is scrolling on the screen in front of him, a complete dataset from twenty-seven research centers globally, involving over four hundred Lynch Syndrome volunteers. This is the familiar path accumulated since Yang Ping’s team launched the "New Plan," which is also the largest verification of system regulation theory.
This laboratory plan can confirm that K Therapy is not just capable of treating Tumors; theoretically, it can target a broader range of diseases. This is the most favorable evidence for the system regulation hypothesis.
"Unbelievable..."
Mainshtan murmured to himself as he is verifying a hypothesis: If the system regulation theory is correct, then volunteers undergoing regulation intervention should exhibit specific regression to a stable mode in their physiological indicators—not a change in a single indicator, but a dynamic trajectory of multi-indicator coordination.
For example, in an effective regulation response: the reduction of colon adenoma should synchronize with the decrease in heterogeneity of TIM expression; the decline in circulating tumor DNA should lag behind the recalibration of immunocyte functions; improvement in intestinal tract microbial diversity should precede the resolution of clinical symptoms, and all these changes should conform to some predictable temporal logic.
For this purpose, Mainshtan had the team develop a complex algorithm to test this hypothesis.
Now, the results are being displayed on the screen.
The first set of graphs: Alina’s data, her indicator changes almost perfectly fit the predicted curve. The correlation coefficient between adenoma shrinkage and TIM stability improvement reached 0.92. The peak of immune activation appeared in the first month, followed by the continuous decline of ctDNA, like a meticulously orchestrated symphony, with each instrument entering at the correct time.
"A perfect case, but maybe just an individual case," Mainshtan told himself.
He pulled up the second, third... tenth... hundredth group of data.
The curves on the screen begin to show diversity; some patients respond faster, some slower. Some fluctuate on certain indicators, but the overall trend is consistent. Mainshtan’s algorithm automatically classifies these trajectories, identifying four main response modes.
Then he associates these response modes with the patients’ genotype, phenotype, microbiome characteristics, among other factors, for analysis.
The results made him hold his breath.
"Found it..."
A significant correlation matrix appeared on the screen. Patients carrying specific TIM variants tend to exhibit a slow, progressive response mode; people with certain Clostridia rich in their intestinal tract have earlier immune recalibration...
This is not only evidence for the efficacy of treatment but also proof of the theoretical prediction power. The system regulation hypothesis not only explains "why it is effective" but also predicts "who it is more effective for" and "in what way it is effective."
This is no longer a hypothesis but a theory confirmed by scientifically rigorous experimentation.
Mainshtan leaned back in his chair, unable to calm down for a long time.
Truth be told, he once held reservations about Yang Ping’s theory—it was too holistic, too philosophical, too difficult to verify. But these data changed everything. He personally witnessed how, when medical intervention shifts from "attacking specific targets" to "regulating the entire system," what occurs is not vague improvement but precise, predictable, and explainable systemic reconstruction.
More shocking is the cross-disease evidence. The Yang Ping team recently extended the regulatory strategy from precancerous lesions to the field of autoimmune diseases. An initial trial targeting systemic lupus erythematosus showed that low-dose specific K Factor intervention reduced disease activity by over 50% in 60% of participants within one month, without the severe side effects of traditional immunosuppressants.
"This is not a coincidence, not the placebo effect," Mainshtan told himself, "This is evidence of a new medical model being born."
He looked at the time, one in the morning. Berlin was silent outside the window, but a surge of emotions was stirring within Mainshtan.
He opened his email and began drafting a long letter.
Recipient: Nobel Prize in Physiology or Medicine Award Selection Committee.
...
Two weeks later, Stockholm, Karolinska Institute.
The Nobel Prize in Physiology or Medicine Award Selection Committee’s closed-door meeting was underway, with five committee members seated around the oak long table, which was scattered with thick nomination materials.
Committee Chair Professor Anna Carlson adjusted her glasses: "Today we discuss a special nomination submitted by Professor Mainshtan from Germany’s Charité Medical College, nominating Chinese scientist Yang Ping, for proposing and verifying the human system regulation theory, ushering in a new era in medical model transition."
An elder committee member frowned: "He has already received the Nobel Prize for Spatial Orientation Gene Theory—this is the second time he is being nominated."
"Yes, that’s correct!" Professor Carlson nodded.
"System regulation? Sounds like integrative medicine or alternative medicine repackaged. We need to be cautious; the Nobel Prize should not be influenced by trends," another committee member questioned.
"I initially thought the same," Professor Carlson activated the projector, "But please look at these data."
The screen displayed a summary of evidence organized by Mainshtan: Lynch Syndrome preventive intervention: 421 cases, three-month follow-up, cancer rate reduced by 89% (compared to historical controls); systemic lupus erythematosus initial trial: 47 cases, average disease activity decreased by 58%...
"More importantly," Professor Carlson switched the chart, "Here are seventeen papers from the Nature, Science, Cell series of Journals, from global teams, independently verifying the core predictions of system regulation theory. Last quarter’s editorial in the New England Journal of Medicine was titled ’Change in Medical Model: From Confrontation to Regulation.’"
